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Graduate School of Science and Engineering
Applied Chemistry

Bioinorganic and Chemical Biology Laboratory

A chemical understanding of life processes

Staff

kodera

Masahito KODERA
[Professor]
MD
Telephone : +81-774-65-6652
kodera
Office : SC-323
Database of Researchers





Yutaka HITOMI
[Professor]
M
Telephone : +81-774-65-7437
hitomi
Office : SC-308
Database of Researchers

Research Topics

  • Development and reaction analysis of enzyme functional model complexes using dinucleating ligands
  • Development of spontaneous construction methods for multinuclear metal complexes displaying enzyme function
  • Development of enzyme functional model complexes that function in water
  • Development of oxidative-stress-sensing probes
  • Development of bio-compatible multifunctional nanoparticles

Research Contents

We aim to deepen a chemical understanding of life processes through the synthesis of artificial molecules that can mimic the masterfully designed reactions that take place within living organisms, and based on this knowledge, we work on the development of functional molecules (catalysts, sensors, etc.) of use to humankind. This approach may be called biomimetics or bio-inspired, and it is expected to become a more and more important approach.
At this laboratory, we are dedicated to developing a group of useful substances by focusing specifically on biological reactions involving metal ions, synthesising artificial molecules that can mimic these in vivo reactions in order to understand life processes at the molecular level. We are also trying to introduce artificial molecules (designed based on an understanding of in vivo reactions) into living cells to examine the chemical reactions within living organisms.

Keywords

  • Dioxygen complex
  • Oxidation reaction
  • Enzyme functional model complex
  • Bio-inspired metal complex
  • Reactive oxygen species
  • Oxidative stress

  • Homeostasis
  • Fluorescent probes
  • Bio-imaging
  • Chemical biology
  • Bioinorganic chemistry

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